Therapeutics , Targets , and Chemical Biology Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Ef fi cacy of Combined MEK and PI 3 K Inhibitors for KRAS-Mutant Lung Cancers

Abstract

Although several groups have demonstrated that concomitant use of MEK and phosphoinositide 3-kinase (PI3K) inhibitors (MEKi/PI3Ki) can induce dramatic tumor regressions in mouse models of KRAS-mutant non– small cell lung cancer (NSCLC), ongoing clinical trials investigating this strategy have been underwhelming to date. While efficacy may be hampered by a… (More)

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