Therapeutics , Targets , and Chemical Biology TargetingERBBReceptorsShifts Their Partners andTriggers Persistent ERK Signaling through a Novel ERBB / EFNB 1 Complex

@inproceedings{Vermeer2013TherapeuticsT,
  title={Therapeutics , Targets , and Chemical Biology TargetingERBBReceptorsShifts Their Partners andTriggers Persistent ERK Signaling through a Novel ERBB / EFNB 1 Complex},
  author={Paola D Vermeer and Paul L Colbert and Bryant G. Wieking and Daniel W Vermeer and John Hyung Lee},
  year={2013}
}
Most squamous cell carcinomas of the head and neck (HNSCC) overexpress ERBB1/EGFR, but EGF receptor (EGFR)-targeted therapies have yielded disappointing clinical results in treatment of this cancer. Here, we describe a novel interaction between EGFR and the ligand EphrinB1 (EFNB1), and we show that EFNB1 phosphorylation and downstream signaling persists in the presence of cetuximab. Mechanistically, cetuximab drives a shift in EGFR dimerization partners within the signaling complex, suggesting… CONTINUE READING

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