Therapeutics , Targets , and Chemical Biology Fes Tyrosine Kinase Expression in the Tumor Niche Correlates with Enhanced Tumor Growth , Angiogenesis , Circulating Tumor Cells , Metastasis , and Infiltrating Macrophages

Fes is a protein tyrosine kinase with cell autonomous oncogenic activities that are well established in cell culture and animal models, but its involvement in human cancer has been unclear. Abundant expression of Fes in vascular endothelial cells and myeloid cell lineages prompted us to explore roles for Fes in the tumor microenvironment. In an orthotopic… CONTINUE READING