Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis.

  title={Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis.},
  author={Birgit Schoeberl and Emily A. Pace and Jonathan B. Fitzgerald and Brian Harms and Lihui Xu and Lin Nie and Bryan Linggi and Ashish Kalra and Violette Paragas and Raghida Bukhalid and Viara Grantcharova and Neeraj Kohli and Kip A. West and Magdalena Leszczyniecka and Michael J. Feldhaus and Arthur J. Kudla and Ulrik B. Nielsen},
  journal={Science signaling},
  volume={2 77},
The signaling network downstream of the ErbB family of receptors has been extensively targeted by cancer therapeutics; however, understanding the relative importance of the different components of the ErbB network is nontrivial. To explore the optimal way to therapeutically inhibit combinatorial, ligand-induced activation of the ErbB-phosphatidylinositol 3-kinase (PI3K) axis, we built a computational model of the ErbB signaling network that describes the most effective ErbB ligands, as well as… CONTINUE READING
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