Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma.

@article{Bag2016TherapeuticallyEI,
  title={Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma.},
  author={Juli Rodriguez Bag{\'o} and Adolfo Alfonso-Pecchio and Onyi Okolie and Raluca Dumitru and Amanda L. Rinkenbaugh and Albert S Baldwin and C Ryan Miller and Scott T. Magness and Shawn D Hingtgen},
  journal={Nature communications},
  year={2016},
  volume={7},
  pages={
          10593
        }
}
Transdifferentiation (TD) is a recent advancement in somatic cell reprogramming. The direct conversion of TD eliminates the pluripotent intermediate state to create cells that are ideal for personalized cell therapy. Here we provide evidence that TD-derived induced neural stem cells (iNSCs) are an efficacious therapeutic strategy for brain cancer. We find that iNSCs genetically engineered with optical reporters and tumouricidal gene products retain the capacity to differentiate and induced… CONTINUE READING
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