Therapeutic window of hyperbaric oxygen therapy for hypoxic–ischemic brain damage in newborn rats

@article{Wang2008TherapeuticWO,
  title={Therapeutic window of hyperbaric oxygen therapy for hypoxic–ischemic brain damage in newborn rats},
  author={Xiao-Li Wang and Yan-song Zhao and Yu-jia Yang and Min Xie and Xiao-he Yu},
  journal={Brain Research},
  year={2008},
  volume={1222},
  pages={87-94}
}
Previous studies showed that hyperbaric oxygen (HBO) promoted cell proliferation in hypoxic-ischemic (HI) neonate rats. Neural stem cells (NSC) existed in the brain lifelong and can be activated. This study was undertaken to assess whether HBO treatment promoted the proliferation of NSC and repaired the brain damage regardless of when it is started, thus to explore the therapeutic window of HBO treatment. Seven-day-old Sprague-Dawley rats underwent left carotid ligation followed by 2 h of… CONTINUE READING
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