Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.

@article{Anderl2011TherapeuticVO,
  title={Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.},
  author={Stefanie Anderl and Megan L Freeland and D. J. Kwiatkowski and June Goto},
  journal={Human molecular genetics},
  year={2011},
  volume={20 23},
  pages={4597-604}
}
Epileptic seizures, particularly infantile spasms, are often seen in infants with tuberous sclerosis complex (TSC) soon after birth. It is feared that there are long-term developmental and cognitive consequences from ongoing, frequent epilepsy. In addition, the hallmark brain pathology of TSC, cortical tubers and giant cells are fully developed at late gestational ages. These observations have led us to examine the benefit of prenatal rapamycin in a new fetal brain model of TSC. In this Tsc1(cc… CONTINUE READING