Therapeutic vaccine for acute and chronic motor neuron diseases: implications for amyotrophic lateral sclerosis.

@article{Angelov2003TherapeuticVF,
  title={Therapeutic vaccine for acute and chronic motor neuron diseases: implications for amyotrophic lateral sclerosis.},
  author={Doychin Nikolov Angelov and Stefan Waibel and Orlando Guntinas-Lichius and Mithra Lenzen and Wolfram Friedrich Neiss and Toma L Tomov and Eti Yoles and Jonathan Kipnis and Hadas Schori and Alexander Reuter and Albert Ludolph and Michal Schwartz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 8},
  pages={4790-5}
}
Therapeutic vaccination with Copaxone (glatiramer acetate, Cop-1) protects motor neurons against acute and chronic degenerative conditions. In acute degeneration after facial nerve axotomy, the number of surviving motor neurons was almost two times higher in Cop-1-vaccinated mice than in nonvaccinated mice, or in mice injected with PBS emulsified in complete Freund's adjuvant (P < 0.05). In mice that express the mutant human gene Cu/Zn superoxide dismutase G93A (SOD1), and therefore simulate… CONTINUE READING
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