Therapeutic vaccination and novel strategies to treat chronic HBV infection.

  title={Therapeutic vaccination and novel strategies to treat chronic HBV infection.},
  author={Antonio Bertoletti and Adam J. Gehring},
  journal={Expert review of gastroenterology & hepatology},
  volume={3 5},
Therapeutic vaccination for the treatment of chronic hepatitis B has so far shown limited clinical efficacy. In this review, we argue that the principal cause of this failure is the profound defect of virus-specific T cells present in chronic hepatitis B patients and we discuss potential new ways to achieve an efficient restoration of virus-specific immunity in patients with chronic hepatitis B virus infection. 

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