Therapeutic trial and pharmacokinetics of sulbactam for uncomplicated gonorrhea in men.

@article{Caine1984TherapeuticTA,
  title={Therapeutic trial and pharmacokinetics of sulbactam for uncomplicated gonorrhea in men.},
  author={Virginia A. Caine and G. Foulds and H. Hunter Handsfield},
  journal={Antimicrobial agents and chemotherapy},
  year={1984},
  volume={26 5},
  pages={
          683-5
        }
}
The efficacy of intramuscular sulbactam for uncomplicated gonorrhea was assessed in 20 men infected with beta-lactamase-negative Neisseria gonorrhoeae. Ten subjects received 2.0 g of sulbactam given in a single intramuscular dose with 1.0 g of probenecid orally; 4 of 10 urethral infections persisted, as did one rectal infection. Ten subjects were treated with 0.5 g of intramuscular sulbactam given twice, 4 h apart; 3 of 10 urethral infections and 2 of 2 rectal infections persisted. The… CONTINUE READING

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