Therapeutic time window of neuroprotection by non-competitive AMPA antagonists in transient and permanent focal cerebral ischemia in rats

@article{Matucz2006TherapeuticTW,
  title={Therapeutic time window of neuroprotection by non-competitive AMPA antagonists in transient and permanent focal cerebral ischemia in rats},
  author={{\'E}va Matucz and K. M{\'o}ricz and G. Gigler and A. Benedek and G. Sz{\'e}n{\'a}si},
  journal={Brain Research},
  year={2006},
  volume={1123},
  pages={60-67}
}
EGIS-8332 and GYKI 53405 are selective, non-competitive AMPA (2-amino-3[3-hydroxy-5-methyl-4-isoxazolyl] propionic acid) antagonists that effectively protected against tissue injury caused by global and focal cerebral ischemia in laboratory animals. This study evaluated the therapeutic time window of neuroprotection by EGIS-8332 and GYKI 53405 in permanent and transient middle cerebral artery occlusion (MCAO) in Sprague-Dawley rats. Infarct size was measured by TTC staining 48 h after permanent… Expand
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References

SHOWING 1-10 OF 33 REFERENCES
A dose-response study of neuroprotection using the AMPA antagonist NBQX in rat focal cerebral ischemia.
  • 54
The effects of AMPA receptor antagonists in models of stroke and neurodegeneration.
  • 37
...
1
2
3
4
...