Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis.

@article{Cao2007TherapeuticTO,
  title={Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis.},
  author={Yihai Cao and Qi Liu},
  journal={Advances in cancer research},
  year={2007},
  volume={97},
  pages={203-24}
}
Like any growing healthy tissues, tumors build up their blood vessels by three mechanisms: angiogenesis, vasculogenesis, and intersucception. Vascular endothelial growth factor-A (VEGF-A) is one of the key factors responsible for stimulation and maintenance of the disorganized, leaky, and torturous tumor vasculature. In addition to VEGF-A, tumors produce multiple other factors to stimulate blood vessel growth. These include members in the platelet-derived growth factor (PDGF), fibroblast growth… CONTINUE READING

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