Therapeutic targets in the ASK1-dependent stress signaling pathways

  title={Therapeutic targets in the ASK1-dependent stress signaling
  author={Ryoichi Hayakawa and Teruyuki Hayakawa and Kohsuke Takeda and Hidenori Ichijo},
  booktitle={Proceedings of the Japan Academy. Series B, Physical and biological sciences},
Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family that activates downstream MAP kinases (MAPKs), c-Jun N-terminal kinases (JNKs) and p38 MAPKs, in response to various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide, and calcium overload. Activation of the JNK and p38 pathways induces stress responses such as cell death, differentiation, and the production of… CONTINUE READING


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