Therapeutic targeting of tumor-stroma interactions.

@article{Hiscox2011TherapeuticTO,
  title={Therapeutic targeting of tumor-stroma interactions.},
  author={Stephen Edward Hiscox and Peter J. Barrett-Lee and Robert Ian Nicholson},
  journal={Expert opinion on therapeutic targets},
  year={2011},
  volume={15 5},
  pages={
          609-21
        }
}
INTRODUCTION Cancers exist within a complex microenvironment populated by diverse cell types within a protein-rich extracellular matrix. It is becoming increasingly apparent that molecular interactions between epithelial cells and cells in the surrounding stroma promote growth, invasion and spread of the tumor itself and thus represents a crucial underlying driving force in tumorigenesis. AREAS COVERED This article reviews how key interactions between tumor epithelial cells and surrounding… CONTINUE READING
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