Therapeutic targeting of splicing in cancer

  title={Therapeutic targeting of splicing in cancer},
  author={Stanley Chun-Wei Lee and O. A. L. Abdel-Wahab},
  journal={Nature Medicine},
Recent studies have highlighted that splicing patterns are frequently altered in cancer and that mutations in genes encoding spliceosomal proteins, as well as mutations affecting the splicing of key cancer-associated genes, are enriched in cancer. In parallel, there is also accumulating evidence that several molecular subtypes of cancer are highly dependent on splicing function for cell survival. These findings have resulted in a growing interest in targeting splicing catalysis, splicing… CONTINUE READING
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