Therapeutic targeting of innate immunity in the failing heart.

  title={Therapeutic targeting of innate immunity in the failing heart.},
  author={Veli Kemal Topkara and Sarah A. Evans and Weili Zhang and Slava Epelman and Lora J Staloch and Philip M. Barger and Douglas L. Mann},
  journal={Journal of molecular and cellular cardiology},
  volume={51 4},
Recent studies suggest that the heart possesses an intrinsic system that is intended to delimit tissue injury, as well as orchestrate homoeostatic responses within the heart. The extant literature suggests that this intrinsic stress response is mediated, at least in part, by a family of pattern recognition receptors that belong to the innate immune system, including CD14, the soluble pattern recognition receptor for lipopolysaccharide, and Toll-like receptors 2, 3, 4, 5, 6, 7, and 9. Although… CONTINUE READING


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Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart

  • W. Chao
  • Am J Physiol Heart Circ Physiol 2009;296:H1–H12
  • 2009

Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice

  • A Riad, S Jager, M Sobirey, F Escher, A Yaulema-Riss, D Westermann
  • J Immunol
  • 2008

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