Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer.

@article{Wigerup2016TherapeuticTO,
  title={Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer.},
  author={Caroline Wigerup and Sven P{\aa}hlman and Daniel Bexell},
  journal={Pharmacology & therapeutics},
  year={2016},
  volume={164},
  pages={
          152-69
        }
}
Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions, hypoxia-inducible factors (HIFs) 1 and 2 are stabilized and mediate a hypoxic response, primarily by acting as transcription factors. HIFs exert differential effects on tumor growth and affect important cancer hallmarks including cell proliferation, apoptosis, differentiation, vascularization/angiogenesis, genetic… CONTINUE READING
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