Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

@inproceedings{Rubinsztein2015TherapeuticTO,
  title={Therapeutic targeting of autophagy in neurodegenerative and infectious diseases},
  author={David C Rubinsztein and Carla F Bento and Vojo Deretic},
  booktitle={The Journal of experimental medicine},
  year={2015}
}
Autophagy is a conserved process that uses double-membrane vesicles to deliver cytoplasmic contents to lysosomes for degradation. Although autophagy may impact many facets of human biology and disease, in this review we focus on the ability of autophagy to protect against certain neurodegenerative and infectious diseases. Autophagy enhances the clearance of toxic, cytoplasmic, aggregate-prone proteins and infectious agents. The beneficial roles of autophagy can now be extended to supporting… CONTINUE READING

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