Therapeutic targeting of angiotensin II receptor type 1 to regulate androgen receptor in prostate cancer.

@article{Takahashi2012TherapeuticTO,
  title={Therapeutic targeting of angiotensin II receptor type 1 to regulate androgen receptor in prostate cancer.},
  author={Satoru Takahashi and Hiroji Uemura and Azman Seeni and Mingxi Tang and Masami Komiya and Ne Long and Hitoshi Ishiguro and Yoshinobu Kubota and Tomoyuki Shirai},
  journal={The Prostate},
  year={2012},
  volume={72 14},
  pages={1559-72}
}
BACKGROUND With the limited strategies for curative treatment of castration-resistant prostate cancer (CRPC), public interest has focused on the potential prevention of prostate cancer. Recent studies have demonstrated that an angiotensin II receptor blocker (ARB) has the potential to decrease serum prostate-specific antigen (PSA) level and improve performance status in CRPC patients. These facts prompted us to investigate the direct effects of ARBs on prostate cancer growth and progression… CONTINUE READING
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