Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials.

@article{Kissin2011TherapeuticTO,
  title={Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials.},
  author={Igor Kissin and Arpad Szallasi},
  journal={Current topics in medicinal chemistry},
  year={2011},
  volume={11 17},
  pages={
          2159-70
        }
}
In primary sensory neurons, the capsaicin receptor TRPV1 functions as a molecular integrator for a broad range of seemingly unrelated chemical and physical noxious stimuli, including heat and altered pH. Indeed, TRPV1 is thought to be a major transducer of the thermal hyperalgesia that follows inflammation and tissue injury as this response is impaired in TRPV1-deficient mice. Following the molecular cloning of TRPV1 in 1997, over a dozen companies embarked on efforts to find clinically useful… CONTINUE READING