Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia

@inproceedings{Roderick2013TherapeuticTO,
  title={Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia},
  author={Justine E. Roderick and Gabriela Gonzalez-Perez and Christina Arieta Kuksin and Anushka Dongre and Emily R. Roberts and Janani Srinivasan and Chester Andrzejewski and Abdul H. Fauq and Todd E Golde and Lucio Miele and Lisa M Minter},
  booktitle={The Journal of experimental medicine},
  year={2013}
}
Severe aplastic anemia (AA) is a bone marrow (BM) failure (BMF) disease frequently caused by aberrant immune destruction of blood progenitors. Although a Th1-mediated pathology is well described for AA, molecular mechanisms driving disease progression remain ill defined. The NOTCH signaling pathway mediates Th1 cell differentiation in the presence of polarizing cytokines, an action requiring enzymatic processing of NOTCH receptors by γ-secretase. Using a mouse model of AA, we demonstrate that… CONTINUE READING

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NOTCH and Graft-Versus-Host Disease

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