Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver

Abstract

During development inhibitor of DNA-bind-2 (Id2) regulates proliferation and differentiation. Id2 expression has been detected in cancer cells, yet its cellular function and validity as a therapeutic target remains largely unknown. Immunohistochemical analysis of colorectal cancer (CRC) specimens revealed that Id2 was undetectable in normal colonic mucosa… (More)
DOI: 10.1038/onc.2008.356

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