Therapeutic targeting of CCR1 attenuates established chronic fungal asthma in mice

@article{Carpenter2005TherapeuticTO,
  title={Therapeutic targeting of CCR1 attenuates established chronic fungal asthma in mice},
  author={Kristin J. Carpenter and Jillian L. Ewing and Jane M. Schuh and Traci L. Ness and Steven L. Kunkel and M{\'o}nica Aparici and Montserrat Miralpeix and Cory M Hogaboam},
  journal={British journal of pharmacology},
  year={2005},
  volume={145 8},
  pages={
          1160-72
        }
}
CC chemokine receptor 1 (CCR1) represents a promising target in chronic airway inflammation and remodeling due to fungus-associated allergic asthma. The present study addressed the therapeutic effect of a nonpeptide CCR1 antagonist, BX-471, in a model of chronic fungal asthma induced by Aspergillus fumigatus conidia. BX-471 treatment of isolated macrophages inhibited CCL22 and TNF-alpha and promoted IL-10 release. BX-471 also increased toll like receptor-9 (TLR9) and decreased TLR2 and TLR6… CONTINUE READING
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