Therapeutic strategy for post-transfusion graft-vs.-host disease.

  title={Therapeutic strategy for post-transfusion graft-vs.-host disease.},
  author={Katsuyasu Saigo and Ryukichi Ryo},
  journal={International journal of hematology},
  volume={69 3},
An effective treatment for post-transfusion graft-vs.-host disease (PT-GVHD), a fatal complication of blood transfusion, has not yet been identified. In this review, we propose a treatment for PT-GVHD based on the mechanism of its onset. First, we briefly review the findings that PT-GVHD is induced by cytotoxic T-lymphocyte (CTL)-mediated tissue injuries through the Fas/Fas ligand system, the perforin/granzyme system, and alloantigen-specific antibodies, as well as through inflammatory… CONTINUE READING