Therapeutic strategies to target multiple kinases in glioblastoma.

  title={Therapeutic strategies to target multiple kinases in glioblastoma.},
  author={Sith Sathornsumetee},
  journal={Anti-cancer agents in medicinal chemistry},
  volume={11 8},
Glioblastoma (GBM), the most common primary brain tumor in adults, is one of the most aggressive human cancers associated with high mortality. Standard treatments following diagnosis include surgical resection, radiotherapy and adjunctive chemotherapy. However, almost all patients develop disease progression following this multimodal therapy. Recent understanding in genomic and molecular abnormalities in GBM has shifted the treatment paradigm towards using molecularly targeted agents. One of… CONTINUE READING