Therapeutic serum concentrations of primidone and its metabolites, phenobarbital and phenylethylmalonamide in epileptic dogs.

@article{Cunningham1983TherapeuticSC,
  title={Therapeutic serum concentrations of primidone and its metabolites, phenobarbital and phenylethylmalonamide in epileptic dogs.},
  author={Janet Cunningham and D Haidukewych and H. Aerenlund Jensen},
  journal={Journal of the American Veterinary Medical Association},
  year={1983},
  volume={182 10},
  pages={1091-4}
}
Fifteen dogs with idiopathic epilepsy were included in a 9-month clinical trial to determine the therapeutic serum concentrations of primidone and its active metabolites, phenobarbital and phenylethylmalonamide. Dogs with a seizure frequency greater than 1/mo or with a record of multiple seizures greater than 1/day were chosen for the study. Each dog was given primidone 3 times daily at dosages intended to maximize seizure control and to minimize undesired side effects. Maintenance period blood… CONTINUE READING