Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.

@article{McCubrey2011TherapeuticRR,
  title={Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.},
  author={James A McCubrey and Linda S. Steelman and Cassandra Kempf and William Harvey Chappell and Stephen L. Abrams and Franca Stivala and Graziella Malaponte and Ferdinando Nicoletti and Massimo Libra and Joerg Baesecke and Danijela Maksimovi{\'c}-Ivani{\'c} and S Nevenka Mijatovi{\'c} and Giuseppe Montalto and Melchiorre Cervello and Lucio Cocco and Alberto M Martelli},
  journal={Journal of cellular physiology},
  year={2011},
  volume={226 11},
  pages={
          2762-81
        }
}
Chemotherapy remains a commonly used therapeutic approach for many cancers. Indeed chemotherapy is relatively effective for treatment of certain cancers and it may be the only therapy (besides radiotherapy) that is appropriate for certain cancers. However, a common problem with chemotherapy is the development of drug resistance. Many studies on the mechanisms of drug resistance concentrated on the expression of membrane transporters and how they could be aberrantly regulated in drug resistant… CONTINUE READING
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