Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks

@inproceedings{Gomez2013TherapeuticRI,
  title={Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks},
  author={German G. Gomez and Jill Wykosky and C. Zanca and Frank B Furnari and Webster K Cavenee},
  booktitle={Cancer biology & medicine},
  year={2013}
}
Receptor tyrosine kinases (RTKs) such as the epidermal growth factor receptor (EGFR) regulate cellular homeostatic processes. EGFR activates downstream signaling cascades that promote tumor cell survival, proliferation and migration. Dysregulation of EGFR signaling as a consequence of overexpression, amplification and mutation of the EGFR gene occurs frequently in several types of cancers and many become dependent on EGFR signaling to maintain their malignant phenotypes. Consequently, concerted… CONTINUE READING

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