Therapeutic receptor targets for lower urinary tract dysfunction

  title={Therapeutic receptor targets for lower urinary tract dysfunction},
  author={Naoki Yoshimura and Yasuhiro Kaiho and Minoru Miyazato and Takakazu Yunoki and Changfeng Tai and Michael B Chancellor and Pradeep Tyagi},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
The functions of the lower urinary tract, to store and periodically release urine, are dependent on the activity of smooth and striated muscles in the bladder, urethra, and external urethral sphincter. During urine storage, the outlet is closed, and the bladder smooth muscle is quiescent. When bladder volume reaches the micturition threshold, activation of a micturition center in the dorsolateral pons (the pontine micturition center) induces a bladder contraction and a reciprocal relaxation of… CONTINUE READING


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Association between bladder overactivity and increased numbers of interstitial cells in the guinea pigs with partial bladder outlet obstruction

  • Y Kubota, Y Kojima, +4 authors K Kohri
  • J Urol
  • 2007
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