Therapeutic proteins: Polymer-perfect proteins

@article{Farley2003TherapeuticPP,
  title={Therapeutic proteins: Polymer-perfect proteins},
  author={Suzanne J. Farley},
  journal={Nature Reviews Drug Discovery},
  year={2003},
  volume={2},
  pages={250-251}
}
  • S. Farley
  • Published 1 April 2003
  • Biology
  • Nature Reviews Drug Discovery
Using chemogenomic techniques, researchers in Seattle describe the design of a novel molecule, PNRI-299, that reduces the inflammation associated with asthma, a disease reaching epidemic proportions worldwide. Asthmatics experience a complex inflammatory response characterized by airway infiltration of immune cells that undergo respiratory burst activation that releases reactive oxygen species (ROS). Redox-sensitive transcription factors, activator protein (AP)-1 and nuclear factor-κB, are… 

References

SHOWING 1-2 OF 2 REFERENCES
Design and Chemical Synthesis of a Homogeneous Polymer-Modified Erythropoiesis Protein
TLDR
The design and total chemical synthesis of SEP, a 51-kilodalton protein-polymer construct consisting of a 166-amino–acid polypeptide chain and two covalently attached, branched, and monodisperse polymer moieties that are negatively charged are reported.
Chemical protein synthesis methods in drug discovery.
  • G. Kochendoerfer
  • Chemistry, Biology
    Current opinion in drug discovery & development
  • 2001
The applicability of chemical protein synthesis over the last five years has been greatly expanded by significant increases in the size (up to 600 amino acids) and variety of accessible proteins,