Therapeutic proteins: Polymer-perfect proteins

  title={Therapeutic proteins: Polymer-perfect proteins},
  author={S. Farley},
  journal={Nature Reviews Drug Discovery},
  • S. Farley
  • Published 2003
  • Medicine
  • Nature Reviews Drug Discovery
Using chemogenomic techniques, researchers in Seattle describe the design of a novel molecule, PNRI-299, that reduces the inflammation associated with asthma, a disease reaching epidemic proportions worldwide. Asthmatics experience a complex inflammatory response characterized by airway infiltration of immune cells that undergo respiratory burst activation that releases reactive oxygen species (ROS). Redox-sensitive transcription factors, activator protein (AP)-1 and nuclear factor-κB, are… Expand