Therapeutic protein-drug interactions and implications for drug development.

Abstract

Many intrinsic and extrinsic factors can affect an individual patient's drug exposure and response. The US Food and Drug Administration (FDA) has published a number of guidances that recommend how and when to evaluate these factors during drug development. The most recent FDA draft guidance on drug interactions provides advice for in vitro and in vivo drug… (More)
DOI: 10.1038/clpt.2009.308

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