Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges.

  title={Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges.},
  author={Svetlana Verenich and Phillip M Gerk},
  journal={Molecular pharmaceutics},
  volume={7 6},
2-Methoxyestradiol (2MeO-E2) is an endogenous metabolite of estrogen which was initially considered to be inactive. During the last few decades it has been shown that 2MeO-E2 is a promising anticancer drug. In vitro experiments have demonstrated that it has several anticancer activities, and potential to alleviate hypertension, glomerulosclerosis, hypercholesterolemia, and other disorders. However, due to its low solubility and extensive glucuronidation, to achieve effective concentrations… CONTINUE READING

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