Therapeutic potential of uracil and its derivatives in countering pathogenic and physiological disorders.

@article{Ramesh2020TherapeuticPO,
  title={Therapeutic potential of uracil and its derivatives in countering pathogenic and physiological disorders.},
  author={Deepthi Ramesh and Balaji Gowrivel Vijayakumar and Tharanikkarasu Kannan},
  journal={European journal of medicinal chemistry},
  year={2020},
  volume={207},
  pages={
          112801
        }
}
Nitrogen Mustard: a Promising Class of Anti-Cancer Chemotherapeutics – a Review
TLDR
Although alkylating agents serve various sub-classes such as nitrosourea, nitrogen mustard, triazide, methanesulphonate, and ethylenimines, this review particularly focused on Nitrogen Mustard, one of the most widely used among all other classes.
Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents
TLDR
Some newly synthesized cyclic and acyclic uracil nucleosides that showed very promising activity against HSV-1 compared to acy Clovir are presented.
Formations of bimolecular barbituric acid complexes through hydrogen bonding interactions: DFT analyses of structural and electronic features
Formations of bimolecular barbituric acid (BA) complexes through hydrogen-bonding (HB) interactions were investigated in this work. BA has been known as a starting compound of pharmaceutical

References

SHOWING 1-10 OF 141 REFERENCES
Clinical Pharmacology of 5-Fluorouracil
Summary5-Fluorouracil, first introduced as a rationally synthesised anticancer agent 30 years ago, continues to be widely used in the management of several common malignancies including cancer of the
Recent advances in pharmacogenetic approaches to anticancer drug development
TLDR
Genotyping strategies based on variants in genes encoding the drug‐metabolizing enzymes thiopurine S‐methyltransferase, dihydropyrimidine dehydrogenase, members of the cytochrome P450 family, including the CYP2B, 2C, 2D, and 3A subfamilies, as well as the UGT family, should eventually lead to improved anticancer chemotherapy.
Tegafur/Uracil + Calcium Folinate in Colorectal Cancer
TLDR
Results have shown that tegafur/uracil at 300 mg/m2/day in divided doses given every 8 hours for 28 days provides prolonged exposure to fluorouracil, which is well tolerated, with dose-limiting toxicity manifesting as diarrhoea.
Trifluridine: A Review of its Antiviral Activity and Therapeutic Use in the Topical Treatment of Viral Eye Infections
TLDR
Trifluridine is an effective alternative to the drugs available for treating herpetic keratitis, and seems especially useful in ‘difficult’ cases, although experience at present is too limited to reliably determine the usual response rate in this difficult therapeutic area.
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