Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents.

  title={Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents.},
  author={Hiroshi Tsutsumi and Tomohiro Tanaka and Nami Ohashi and Hiroyuki Masuno and Hirokazu Tamamura and Kenichi Hiramatsu and Takanobu Araki and Satoshi Ueda and Shinya Oishi and Nobutaka Fujii},
  volume={88 2},
The chemokine receptor CXCR4 possesses multiple critical functions in normal and pathologic physiology. CXCR4 is a G-protein-coupled receptor that transduces signals of its endogenous ligand, the chemokine CXCL12 (stromal cell-derived factor-1, SDF-1). The interaction between CXCL12 and CXCR4 plays an important role in the migration of progenitors during embryologic development of the cardiovascular, hemopoietic, central nervous systems, and so on. This interaction is also known to be involved… CONTINUE READING


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