Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome.


Nitrite is a storage reservoir of nitric oxide that is readily reduced to nitric oxide under pathological conditions. Previous studies have demonstrated that nitrite levels are significantly reduced in cardiovascular disease states, including peripheral vascular disease. We investigated the cytoprotective and proangiogenic actions of a novel, sustained… (More)
DOI: 10.1152/ajpheart.00115.2015


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