Therapeutic potential of somatic cell nuclear transfer for degenerative disease caused by mitochondrial DNA mutations

@inproceedings{Greggains2014TherapeuticPO,
  title={Therapeutic potential of somatic cell nuclear transfer for degenerative disease caused by mitochondrial DNA mutations},
  author={Gareth D. Greggains and Lisa Lister and Helen A. L. Tuppen and Qi Zhang and Louise H. Needham and Niledran S Prathalingam and Louise Ann Hyslop and Lyndsey Craven and Zbigniew Polański and Alison P. Murdoch and Douglass Matthew Turnbull and Mary Herbert},
  booktitle={Scientific reports},
  year={2014}
}
Induced pluripotent stem cells (iPSCs) hold much promise in the quest for personalised cell therapies. However, the persistence of founder cell mitochondrial DNA (mtDNA) mutations limits the potential of iPSCs in the development of treatments for mtDNA disease. This problem may be overcome by using oocytes containing healthy mtDNA, to induce somatic cell nuclear reprogramming. However, the extent to which somatic cell mtDNA persists following fusion with human oocytes is unknown. Here we show… CONTINUE READING
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