Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data

@article{Black2004TherapeuticPO,
  title={Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data},
  author={Mark D. Black},
  journal={Psychopharmacology},
  year={2004},
  volume={179},
  pages={154-163}
}
  • M. Black
  • Published 26 January 2005
  • Biology, Psychology
  • Psychopharmacology
BackgroundPositive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) modulators enhance glutamate transmission via the AMPA receptor by altering the rate of desensitization; alone they have no intrinsic activity. They are the only class of compounds known that may pharmacologically separate AMPA subtypes.ObjectiveThis manuscript will review preclinical work on positive AMPA modulators, with clinical examples where relevant.ResultsThe activity of these compounds appears to be… 

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