Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes.

@article{Han2008TherapeuticPO,
  title={Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes.},
  author={Kyu Lee Han and Joo Sun Choi and Jae Young Lee and Jihyun Song and Myung Kuk Joe and Myeong Ho Jung and J O Hwang},
  journal={Diabetes},
  year={2008},
  volume={57 3},
  pages={737-45}
}
OBJECTIVE Peroxisome proliferator-activated receptor (PPAR) alpha/gamma dual agonists have the potential to be used as therapeutic agents for the treatment of type 2 diabetes. This study evaluated the function of macelignan, a natural compound isolated from Myristica fragrans, as a dual agonist for PPARalpha/gamma and investigated its antidiabetes effects in animal models. RESEARCH DESIGN AND METHODS GAL4/PPAR chimera transactivation was performed and the expression of PPARalpha/gamma target… CONTINUE READING

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