Therapeutic potential of pegylated hemin for reactive oxygen species-related diseases via induction of heme oxygenase-1: results from a rat hepatic ischemia/reperfusion injury model.

@article{Fang2011TherapeuticPO,
  title={Therapeutic potential of pegylated hemin for reactive oxygen species-related diseases via induction of heme oxygenase-1: results from a rat hepatic ischemia/reperfusion injury model.},
  author={Jun Fang and Haibo Qin and Takahiro Seki and Hideaki Nakamura and Kenji Tsukigawa and Takashi Shin and Hiroshi Maeda},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={339 3},
  pages={779-89}
}
Many diseases and pathological conditions, including ischemia/reperfusion (I/R) injury, are the consequence of the actions of reactive oxygen species (ROS). Controlling ROS generation or its level may thus hold promise as a standard therapeutic modality for ROS-related diseases. Here, we assessed heme oxygenase-1 (HO-1), which is a crucial antioxidative… CONTINUE READING