Therapeutic potential of interleukin-17 in inflammation and autoimmune diseases.

Abstract

INTRODUCTION Interleukin-17 (IL-17) is a proinflammatory cytokine that mainly produced by T helper 17 (Th17) cells. In this article, we discussed the role of IL-17 in inflammation and autoimmune diseases, and the therapeutic strategies targeting IL-17. AREAS COVERED In this article, we discussed the proinflammatory cytokine IL-17 and IL-17 receptors signals, and their regulation. IL-17 expression was abnormal in the bacterium, virus and fungus infection, and its higher level caused the tissue inflammation. IL-17 was involved in the pathological process of autoimmune diseases, such as systemic sclerosis, rheumatoid arthritis, ankylosing spondylitis and systemic lupus erythematosus, and IL-17 has been put as a therapeutic target in the clinic. EXPERT OPINION IL-17/IL-17R signals and their application in inflammation process still need to be explored. Therapeutic strategies targeting IL-17 in autoimmune diseases ameliorated the inadequate response to anti-TNF-α therapy.

DOI: 10.1517/14728222.2013.843669

Cite this paper

@article{Yan2014TherapeuticPO, title={Therapeutic potential of interleukin-17 in inflammation and autoimmune diseases.}, author={Jun-wei Yan and Yu-Jie Wang and Wen-jia Peng and Jin-Hui Tao and Ya-nan Wan and Bao-Zhu Li and Bin Mei and Bing Chen and Hua Yao and Guo-jun Yang and Xiang-pei Li and Dong Ye and Jing Wang}, journal={Expert opinion on therapeutic targets}, year={2014}, volume={18 1}, pages={29-41} }