• Biology, Medicine
  • Published in Anticancer research 1996

Therapeutic potential of humanized anti-interleukin-6 receptor antibody: antitumor activity in xenograft model of multiple myeloma.

@article{Tsunenari1996TherapeuticPO,
  title={Therapeutic potential of humanized anti-interleukin-6 receptor antibody: antitumor activity in xenograft model of multiple myeloma.},
  author={Toshiaki Tsunenari and Ken‐ichi Akamatsu and S i Kaiho and Keisuke Sato and Masayuki Tsuchiya and Yasuo Gotenba-shi Koishihara and Toshimitsu Kishimoto and Yoshiyuki Ohsugi},
  journal={Anticancer research},
  year={1996},
  volume={16 5A},
  pages={
          2537-44
        }
}
A xenograft model of human multiple myeloma (MM) was established in athymic nude mice using S6B45 cells whose growth is dependent on IL-6 in an autocrine fashion. S6B45 cells were inoculated s.c. into mice pretreated with 500 cGy X-ray and anti-asialo GM1 antibody. In more than 90% of the mice, a palpable tumor emerged within 30 days at the inoculation site. Histological observation of the tumor section revealed that the tumor mass was composed of two different phenotypes of myeloma cells… CONTINUE READING