Therapeutic potential of endothelin receptor antagonists in experimental stroke.

@article{Patel1995TherapeuticPO,
  title={Therapeutic potential of endothelin receptor antagonists in experimental stroke.},
  author={Toshal R Patel and Sally Galbraith and morera mcauley and Annette M. Doherty and David I. Graham and J Mcculloch},
  journal={Journal of cardiovascular pharmacology},
  year={1995},
  volume={26 Suppl 3},
  pages={S412-5}
}
This investigation demonstrates an increase in endothelin (ET)-mediated vascular tone in peri-ischemic areas after experimental focal cerebral ischemia (middle cerebral artery occlusion) in the cat. Adventitial application of the butenolide antagonist PD155080 (30 microM), after MCA occlusions resulted in marked increases in caliber of dilated (10.6 +/- 1.6% change from preinjection baseline) and constricted vessels (68.7 +/- 17.5% change from pre-injection baseline). Cerebral blood flow… CONTINUE READING