Therapeutic potential of dendritic cell-based immunization against HBV in transgenic mice.

@article{Jiang2008TherapeuticPO,
  title={Therapeutic potential of dendritic cell-based immunization against HBV in transgenic mice.},
  author={Wen-zheng Jiang and Yan Liang Fan and Xia Liu and Yali Zhang and Jie-jun Wen and Wen-li Hao and Min Qian},
  journal={Antiviral research},
  year={2008},
  volume={77 1},
  pages={50-5}
}
Hepatitis B virus (HBV) transgenic mice that express HBV envelope proteins represent a model of chronic HBV infection suitable for the development of therapeutic immunization strategies. To address immunologically therapeutic effects induced by peptide-pulsed DCs, HBV transgenic mice were immunized with peptide-pulsed DCs, and the mice were killed after three times of immunization and the splenocytes were stimulated in vitro and detected by IFN-gamma ELISPOT and cytotoxic T lymphocyte (CTL… CONTINUE READING