Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism

  title={Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism},
  author={Chia-Wei Phan and Pamela David and Murali Naidu and Kah-Hui Wong and Vikineswary Sabaratnam},
  journal={Critical Reviews in Biotechnology},
  pages={355 - 368}
Mushrooms have long been used not only as food but also for the treatment of various ailments. [] Key Result The mushrooms (either extracts from basidiocarps/mycelia or isolated compounds) reduced beta amyloid-induced neurotoxicity and had anti-acetylcholinesterase, neurite outgrowth stimulation, nerve growth factor (NGF) synthesis, neuroprotective, antioxidant, and anti-(neuro)inflammatory effects.

Role of Mushrooms in Neurodegenerative Diseases

These mushrooms’ extracts from basidiocarps/mycelia or isolated compounds have been known to decrease neurotoxicity through various neuroprotective molecular mechanisms such as anti-acetylcholinesterase activity, neurite outgrowth stimulation (neuritogenic), and nerve growth factor (NGF) synthesis (neurotrophic), enhancing mitochondrial functions and reducing endoplasmic reticulum (ER) stress, in addition to antioxidant and anti-inflammatory effects.

The Bioactive Compounds in Medicinal Mushrooms have Potential Protective Effects against Neurodegenerative Diseases

More animal and human studies are needed in the future to confirm the anti-neurodegenerative effects and understand the mechanism of the protective action of these bioactive compounds.

Edible and Medicinal Mushrooms: Emerging Brain Food for the Mitigation of Neurodegenerative Diseases.

In this review, the scientific information on edible and culinary mushrooms with regard to their antidementia/AD active compounds and/or pharmacological test results are summarized and may be regarded as functional foods for the mitigation of neurodegenerative diseases.

Edible Mushrooms as Neuro-nutraceuticals: Basis of Therapeutics

Mushrooms, the macro-fungi with distinctive fruiting bodies and mycelia, are valued throughout the world not only for their nutritive values but also for their medicinal uses. The former desirable

Recent Progress in Research on the Pharmacological Potential of Mushrooms and Prospects for Their Clinical Application

This review discusses recent advances in research on the pharmacological potential of mushrooms and perspectives for their clinical application.

The Neurotrophic and Neuroprotective Potential of Macrofungi

This review discusses recent advances in research on the neuroprotective potential of macrofungi and perspectives for their application as neuroprotectants in biomedicine to prevent, support, or cure neurodegenerative disorders.

Bioactives from Mushroom and Their Application

It is very important to improve and optimize conditions for mycelial growth in vitro and create new strains by genetic modification in order to produce large amounts of those compounds of interest.

A review of the therapeutic and biological effects of edible and wild mushrooms

This review aims to provide a clear insight on the commercially cultivated, wild edible, and medicinal mushrooms with comprehensive information on their phytochemical constituents and properties as part of food and medicine for futuristic exploitation.



Neuronal Health – Can Culinary and Medicinal Mushrooms Help?

Hericium erinaceus a culinary and medicinal mushroom is a well established candidate for brain and nerve health, and indigenous mushrooms used in traditional medicines such as Lignosus rhinocerotis and Ganoderma neo-japonicum are also being investigated.

Medicinal Plants and Dementia Therapy: Herbal Hopes for Brain Aging?

A multi‐faceted review of medicinal plants or phytochemicals, including traditional uses, relevant bioactivities, psychological and clinical evidence on efficacy and safety, focuses on those for which there is promising clinical trial evidence in people with dementia, together with at least one other of these lines of supporting evidence.

Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells

The present study reports the first evidence of the neuritogenic effects of aqueous extracts of basidiocarps of G. neo-japonicum and G. frondosa, which may contain NGF-like bioactive compound(s) for maintaining and regenerating the neuronal communications network.

Pleurotus giganteus (Berk.) Karunarathna & K.D. Hyde: Nutritional value and in vitro neurite outgrowth activity in rat pheochromocytoma cells

Inhibition treatment results suggested that MEK/ERK and PI3K/Akt are responsible for neurite outgrowth of PC12 cells stimulated by P. giganteus extract, and this mushroom may be developed as a nutraceutical for the mitigation of neurodegenerative diseases.

Chemical, pharmacological, and biological characterization of the culinary-medicinal honey mushroom, Armillaria mellea (Vahl) P. Kumm. (Agaricomycetideae): a review.

The mechanism of symbiosis between A. mellea and the orchid species Gastrodia elata, which is native to Asia, Australia, and New Zealand, and used in therapeutics in official Chinese medicine, is described.

Determination of anti-inflammatory activities of standardised preparations of plant- and mushroom-based foods

Anti-inflammatory activity in these food samples survived ‘cooking’ and may be useful in limiting inflammation in a variety of age-related inflammatory diseases, and could be a source for the discovery of novel anti-inflammatory drugs.

Heat-stable components of wood ear mushroom, Auricularia polytricha (higher Basidiomycetes), inhibit in vitro activity of beta secretase (BACE1).

The consumption of mushrooms has been linked with protection against dementia, including Alzheimer's disease (AD), by several biological pathways including inhibiting beta-site APP-cleaving enzyme

Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.

The aqueous extract of H. erinaceus contained neuroactive compounds which induced NGF-synthesis and promoted neurite outgrowth in NG108-15 cells, and the extract also enhanced the neuriteOutgrowth stimulation activity of NGF when applied in combination.

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice.

The mushroom Hericium erinaceus prevented impairments of spatial short-term and visual recognition memory induced by amyloid β(25-35) peptide, indicating that H. erinACEus may be useful in the prevention of cognitive dysfunction.