Therapeutic potential of chimeric anti-(ganglioside GD3) antibody KM871: antitumor activity in xenograft model of melanoma and effector function analysis

Abstract

KM871 is a chimeric antibody recognizing ganglioside GD3, which is one of the major gangliosides expressed on the cell surface of human tumors of neuroectodermal origin. This study demonstrates the antitumor activity of KM871 against human melanoma xenografts in nude mice, and analyzes the effector function operating in mice. In a well-established tumor… (More)
DOI: 10.1007/s002620000101

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@article{Kanazawa2000TherapeuticPO, title={Therapeutic potential of chimeric anti-(ganglioside GD3) antibody KM871: antitumor activity in xenograft model of melanoma and effector function analysis}, author={Junji Kanazawa and So Ohta and Kenya Shitara and Fumiko Fujita and Masahide Fujita and Nobuo Hanai and Shiro Akinaga and Masami Okabe}, journal={Cancer Immunology, Immunotherapy}, year={2000}, volume={49}, pages={253-258} }