Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma

@article{Naramura1993TherapeuticPO,
  title={Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma},
  author={Mayumi Naramura and Stephen D Gillies and John Martin. Mendelsohn and Ralph A. Reisfeld and Barbara M. Mueller},
  journal={Cancer Immunology, Immunotherapy},
  year={1993},
  volume={37},
  pages={343-349}
}
On many tumors, high numbers of epidermal growth factor (EGF) receptors provide a target for antibody-mediated tumor therapy. We evaluate here the therapeutic potential of a mouse/human chimeric anti-(EGF receptor) antibody and compare it to the parental murine antibody in a xenograft model for metastatic melanoma. Our model is based on the human cell line M24met, which overexpresses the EGF receptor and metastasizes spontaneously in SCID mice. Both the chimeric anti-(EGF receptor) antibody… CONTINUE READING
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