Therapeutic potential of cannabinoid receptor agonists as analgesic agents.

  title={Therapeutic potential of cannabinoid receptor agonists as analgesic agents.},
  author={Alyson J. Fox and Stuart Bevan},
  journal={Expert opinion on investigational drugs},
  volume={14 6},
Increasing data emerging from controlled clinical trials support an analgesic activity of cannabinoids. However, the psychotropic side effects associated with tetrahydrocannabinol or synthetic derivatives essentially puts a brake on their use, possibly limiting the degree of analgesia that can be achieved as well as providing regulatory hurdles. Animal studies show that although these side effects are mediated via central cannabinoid type 1 (CB(1)) receptors, the analgesic activity in chronic… CONTINUE READING
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