Therapeutic potential of antibodies against FZD10, a cell-surface protein, for synovial sarcomas

Abstract

Genome-wide expression profiling revealed overexpression of the gene encoding frizzled homologue 10 (FZD10), a cell-surface receptor for molecules in the Wnt pathway, as a potential contributor to synovial sarcomas (SS). Northern blotting and immunohistochemical staining confirmed that expression levels of FZD10 were very high in nearly all SS tumors and… (More)
DOI: 10.1038/sj.onc.1208780

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