Therapeutic potential of a fully human monoclonal antibody against influenza A virus M2 protein.

@article{Wang2008TherapeuticPO,
  title={Therapeutic potential of a fully human monoclonal antibody against influenza A virus M2 protein.},
  author={Rongfang Wang and Aihua Song and James Levin and Dawna Dennis and Noelle Jie Zhang and Hitoshi Yoshida and Lilia K. Koriazova and Lydia Madura and Laura R Shapiro and Atsushi Matsumoto and Hideaki Yoshida and Toshifumi Mikayama and Ralph T. Kubo and Sally Sarawar and Hilde Cheroutre and Shinichiro Kato},
  journal={Antiviral research},
  year={2008},
  volume={80 2},
  pages={168-77}
}
Influenza is one of the most prevalent viral diseases in humans. For some high-risk human populations, including the infant, the elderly, and the immunocompromised, who may not benefit from active immunization, passive immunotherapy with antibodies reactive with all influenza A strains may be an alternative. In this study, we characterized several fully human monoclonal antibodies (MAb) reactive with M2e, which were generated from transchromosomic mice engineered to produce fully human… CONTINUE READING
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