Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer

@inproceedings{Ooki2010TherapeuticPO,
  title={Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer},
  author={Akira Ooki and Keishi Yamashita and Shiro Kikuchi and Shinichi Sakuramoto and Natsuya Katada and Mina Waraya and Hiroshi Kawamata and Hiroshi Nishimiya and Kazunori Nakamura and Masahiko Watanabe},
  booktitle={BMC Cancer},
  year={2010}
}
Phosphatase of regenerating liver-3 (PRL-3) has deserved attention as a crucial molecule in the multiple steps of metastasis. In the present study, we examined the mechanisms regulating PRL-3 expression, and assessed the clinical potential of PRL-3-targeted therapy in gastric cancer. PRL-3 genomic amplification was analyzed using quantitative-polymerase chain reaction and/or fluorescence in situ hybridization in 77 primary gastric tumors. The anticancer activity of PRL-3 inhibitor (1-4-bromo-2… CONTINUE READING
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